However, researchers at the Salk Institute for Biological Studies believe the cure to Alzheimer's disease might come from a readily available substance: marijuana.
In order to test their theory, researchers at the Salk Institute modified nerve cells to produce high levels of beta-amyloid. Researchers then noted that these higher levels of beta-amyloid production led to the expression of pro-inflammatory proteins and eventually nerve cell death. The ongoing death of these nerve cells is what leads to the progressive cognitive decline witnessed in Alzheimer's patients. This itself was an intriguing finding, as it was long believed that an immune-like response, not the proteins themselves, led to nerve cell death.
Now here's where things get interesting. As the researchers noted in their findings, nerve cells in the brain contain receptors that are activated by lipid molecules known as endocannabinoids, which are naturally produced by nerve cells. These endocannabinoids are believed to help nerve cells with their ability to send signals relating to appetite, pain sensation, and memory. Marijuana contains the chemical tetrahydrocannabinol (more commonly known as THC), which is similar to endocannabinoids and can activate those same nerve cell receptors. In other words, the researchers at Salk Institute hypothesized that cannabis could block the receptors that lead to the release of pro-inflammatory proteins and prevent nerve cell death.
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