Tuesday, March 10, 2015

Liar, Liar


Conservative Activists: Scott Walker Has Best Shot at Beating Hillary Clinton

National Journal ^ | March 9, 2015 | Shane Goldmacher 

A new survey of conservative activists shows many in the movement see Wisconsin Gov. Scott Walker as the strongest Republican to take on Hillary Clinton in 2016.
The survey wasn't scientific. But conservative activist group ForAmerica surveyed almost 10,000 of its Facebook members and more than 32 percent said Walker has the "best shot at beating Hillary Clinton" in the field, according to results shared first with National Journal.
Ben Carson, a neurosurgeon who has never held elected office, finished in second, with nearly 25 percent of the vote.
Sen. Ted Cruz (14 percent), Sen. Rand Paul (6.6 percent) and Jeb Bush (3.9 percent) rounded out the top five. Bush, who is expected to blow past his potential presidential rivals in fundraising this quarter, also finished fifth in the recent Conservative Political Action Conference straw poll.
ForAmerica, which is run by David Bozell and chaired by his father, Brent Bozell, has vowed to hold Republicans' feet to the fire in 2016 for hewing to a conservative line. Already, the group has skewered Bush for giving Clinton a public service award.
The ForAmerica survey included eight candidates (the others were Rick Perry, who finished with 3.3 percent, and Bobby Jindal and Chris Christie at 1.9 percent apiece). Members could also pencil in others, and Mike Huckabee led the write-in category, receiving pulling in 1.3 percent.
In anonymous comments shared by ForAmerica that accompanied the survey, the GOP activists didn't sound particularly enthused with the field. "We are screwed!!" lamented one. "None of these jokers," chimed in another.

Scientists find class of drugs that boosts healthy lifespan

MedicalXpress ^ | 3/9/15 

A research team from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions has identified a new class of drugs that in animal models dramatically slows the aging process—alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan.
The new research was published March 9 online ahead of print by the journal Aging Cell.
The scientists coined the term "senolytics" for the new class of drugs. "We view this study as a big, first step toward developing treatments that can be given safely to patients to extend healthspan or to treat age-related diseases and disorders," said TSRI Professor Paul Robbins, PhD, who with Associate Professor Laura Niedernhofer, MD, PhD, led the research efforts for the paper at Scripps Florida. "When senolytic agents, like the combination we identified, are used clinically, the results could be transformative."
"The prototypes of these senolytic agents have more than proven their ability to alleviate multiple characteristics associated with aging," said Mayo Clinic Professor James Kirkland, MD, PhD, senior author of the new study. "It may eventually become feasible to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time."
Finding the Target
Senescent cells—cells that have stopped dividing—accumulate with age and accelerate the aging process. Since the "healthspan" (time free of disease) in mice is enhanced by killing off these cells, the scientists reasoned that finding treatments that accomplish this in humans could have tremendous potential.
The scientists were faced with the question, though, of how to identify and target senescent cells without damaging other cells.
The team suspected that senescent cells' resistance to death by stress and damage could provide a clue. Indeed, using transcript analysis, the researchers found that, like cancer cells, senescent cells have increased expression of "pro-survival networks" that help them resist apoptosis or programmed cell death. This finding provided key criteria to search for potential drug candidates.
Using these criteria, the team homed in on two available compounds—the cancer drug dasatinib (sold under the trade name Sprycel) and quercetin, a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.
Further testing in cell culture showed these compounds do indeed selectively induce death of senescent cells. The two compounds had different strong points. Dasatinib eliminated senescent human fat cell progenitors, while quercetin was more effective against senescent human endothelial cells and mouse bone marrow stem cells. A combination of the two was most effective overall.
Remarkable Results
Next, the team looked at how these drugs affected health and aging in mice.
"In animal models, the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, and extended healthspan," said Niedernhofer, whose animal models of accelerated aging were used extensively in the study. "Remarkably, in some cases, these drugs did so with only a single course of treatment."
In old mice, cardiovascular function was improved within five days of a single dose of the drugs. A single dose of a combination of the drugs led to improved exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months following treatment with the drugs. Periodic drug administration of mice with accelerated aging extended the healthspan in the animals, delaying age-related symptoms, spine degeneration and osteoporosis.
The authors caution that more testing is needed before use in humans. They also note both drugs in the study have possible side effects, at least with long-term treatment.
The researchers, however, remain upbeat about their findings' potential. "Senescence is involved in a number of diseases and pathologies so there could be any number of applications for these and similar compounds," Robbins said. "Also, we anticipate that treatment with senolytic drugs to clear damaged cells would be infrequent, reducing the chance of side effects."



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